What truly matters when creating custom MTG cards is finding the right value-to-cost ratio for each one and considering appropriate levels of power for different rarities
The main theme of Azurite Sea may focus on pirates, but its most valuable Lorcana card is actually Baymax
Its going to be $10, like Jadelight Ranger was) Sell six months before rotation: Carnage Tyrant, History of Benalia Buy when it rotates and is cheapest: Mox Amber (going to get broken at some point, already ticking up in Commander), The Immortal Sun
His Mardu colour identity is important too, allowing the deck to break outside of the usual Rakdos colours for vampires and include all the white vampires that have been printed in recent times, as well as providing access to enchantment removal which historically black and red have struggled with
Yawgmoth, Thran Physician The creator of those Phyrexians who've been causing such a bother lately, Yawmoth, Thran Physician is a much-desired card in both Modern and Commander, valued at $41